AustralieFrV1, Main, Exploration, bibRecord, 003252

A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome

Identifieur interne : 003252 ( Main/Exploration ); précédent : 003251; suivant : 003253

A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome

Source :

Nature genetics [ 1061-4036 ] ; 2015.

RBID : PMC:4605818

Descripteurs français

KwdFr :
- Animaux, Canaux calciques (génétique), Cartographie chromosomique, Cellules HEK293, Cellules HeLa, Cellules MCF-7, Cellules cancéreuses en culture, Glaucome capsulaire (génétique), Glaucome capsulaire (épidémiologie), Glaucome à angle ouvert (génétique), Glaucome à angle ouvert (épidémiologie), Humains, Japon (épidémiologie), Polymorphisme de nucléotide simple, Population d'origine asiatique (), Population d'origine asiatique (génétique), Prédisposition génétique à une maladie, Souris, Souris de lignée C57BL, Étude d'association pangénomique, Études cas-témoins.
MESH :
- génétique : Canaux calciques, Glaucome capsulaire, Glaucome à angle ouvert, Population d'origine asiatique.
- épidémiologie : Glaucome capsulaire, Glaucome à angle ouvert, Japon.
- Animaux, Cartographie chromosomique, Cellules HEK293, Cellules HeLa, Cellules MCF-7, Cellules cancéreuses en culture, Humains, Polymorphisme de nucléotide simple, Population d'origine asiatique, Prédisposition génétique à une maladie, Souris, Souris de lignée C57BL, Étude d'association pangénomique, Études cas-témoins.
Wicri :
- geographic : Japon.

English descriptors

KwdEn :
- Animals, Asian Continental Ancestry Group (genetics), Asian Continental Ancestry Group (statistics & numerical data), Calcium Channels (genetics), Case-Control Studies, Chromosome Mapping, Exfoliation Syndrome (epidemiology), Exfoliation Syndrome (genetics), Genetic Predisposition to Disease, Genome-Wide Association Study, Glaucoma, Open-Angle (epidemiology), Glaucoma, Open-Angle (genetics), HEK293 Cells, HeLa Cells, Humans, Japan (epidemiology), MCF-7 Cells, Mice, Mice, Inbred C57BL, Polymorphism, Single Nucleotide, Tumor Cells, Cultured.
MESH :
- chemical , genetics : Calcium Channels.
- geographic , epidemiology : Japan.
- epidemiology : Exfoliation Syndrome, Glaucoma, Open-Angle.
- genetics : Asian Continental Ancestry Group, Exfoliation Syndrome, Glaucoma, Open-Angle.
- statistics & numerical data : Asian Continental Ancestry Group.
- Animals, Case-Control Studies, Chromosome Mapping, Genetic Predisposition to Disease, Genome-Wide Association Study, HEK293 Cells, HeLa Cells, Humans, MCF-7 Cells, Mice, Mice, Inbred C57BL, Polymorphism, Single Nucleotide, Tumor Cells, Cultured.

Abstract

Exfoliation syndrome (XFS) is the commonest recognizable cause of open angle glaucoma world-wide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) on 1,484 patients and 1,188 controls from Japan, and followed up the most significant findings on a further 6,901 patients and 20,727 controls from 17 countries across 6 continents. We discovered a significant association between a new locus (CACNA1A rs4926244) and increased susceptibility to XFS (Odds ratio [OR] = 1.16, P = 3.36 × 10⁻¹¹). Although overwhelming association at the LOXL1 locus was confirmed, the key SNP marker (LOXL1 rs4886776) demonstrated allelic reversal depending on ethnic grouping (In Japanese: OR_A-allele= 9.87, P = 2.13 × 10⁻²¹⁷; In non-Japanese: OR_A-allele= 0.49, P = 2.35 × 10⁻³¹). Our findings represent the first genetic locus outside of LOXL1 which surpasses genome-wide significance for XFS, and provides insight into the biology and pathogenesis of the disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605818

DOI: 10.1038/ng.3226
PubMed: 25706626
PubMed Central: 4605818

Affiliations:

Le document en format XML

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<author><name sortKey="Zenteno, Juan C" sort="Zenteno, Juan C" uniqKey="Zenteno J" first="Juan C." last="Zenteno">Juan C. Zenteno</name>
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<author><name sortKey="Zarnowski, Tomasz" sort="Zarnowski, Tomasz" uniqKey="Zarnowski T" first="Tomasz" last="Zarnowski">Tomasz Zarnowski</name>
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<author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name>
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<affiliation wicri:level="3"><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff>
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<wicri:regionArea>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing</wicri:regionArea>
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<author><name sortKey="Williams, Susan" sort="Williams, Susan" uniqKey="Williams S" first="Susan" last="Williams">Susan Williams</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg</wicri:regionArea>
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<author><name sortKey="Paoli, Daniela" sort="Paoli, Daniela" uniqKey="Paoli D" first="Daniela" last="Paoli">Daniela Paoli</name>
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<wicri:regionArea>Department of Ophthalmology, Monfalcone Hospital, Gorizia</wicri:regionArea>
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<author><name sortKey="Schlottmann, Patricio G" sort="Schlottmann, Patricio G" uniqKey="Schlottmann P" first="Patricio G" last="Schlottmann">Patricio G. Schlottmann</name>
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<author><name sortKey="Huang, Lulin" sort="Huang, Lulin" uniqKey="Huang L" first="Lulin" last="Huang">Lulin Huang</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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<affiliation wicri:level="1"><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu</wicri:regionArea>
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</author>
<author><name sortKey="Sim, Kar Seng" sort="Sim, Kar Seng" uniqKey="Sim K" first="Kar Seng" last="Sim">Kar Seng Sim</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
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</author>
<author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
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<author><name sortKey="Kumar, Rajesh S" sort="Kumar, Rajesh S" uniqKey="Kumar R" first="Rajesh S" last="Kumar">Rajesh S. Kumar</name>
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<wicri:regionArea>Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010</wicri:regionArea>
<wicri:noRegion>Bangalore 560 010</wicri:noRegion>
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</author>
<author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
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</author>
<author><name sortKey="Manabe, Shin Ichi" sort="Manabe, Shin Ichi" uniqKey="Manabe S" first="Shin-Ichi" last="Manabe">Shin-Ichi Manabe</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka</wicri:regionArea>
<wicri:noRegion>Fukuoka</wicri:noRegion>
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</author>
<author><name sortKey="Hayashi, Ken" sort="Hayashi, Ken" uniqKey="Hayashi K" first="Ken" last="Hayashi">Ken Hayashi</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka</wicri:regionArea>
<wicri:noRegion>Fukuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kazama, Shigeyasu" sort="Kazama, Shigeyasu" uniqKey="Kazama S" first="Shigeyasu" last="Kazama">Shigeyasu Kazama</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035,Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035</wicri:regionArea>
<wicri:noRegion>Miyazaki 880-0035</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ideta, Ryuichi" sort="Ideta, Ryuichi" uniqKey="Ideta R" first="Ryuichi" last="Ideta">Ryuichi Ideta</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Ideta Eye Hospital, Kumamoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Ideta Eye Hospital, Kumamoto</wicri:regionArea>
<wicri:noRegion>Kumamoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mori, Yosai" sort="Mori, Yosai" uniqKey="Mori Y" first="Yosai" last="Mori">Yosai Mori</name>
<affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff>
<wicri:noCountry code="subfield">Miyazaki 885-0051 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Miyata, Kazunori" sort="Miyata, Kazunori" uniqKey="Miyata K" first="Kazunori" last="Miyata">Kazunori Miyata</name>
<affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff>
<wicri:noCountry code="subfield">Miyazaki 885-0051 Japan</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki</wicri:regionArea>
<wicri:noRegion>Miyazaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sugiyama, Kazuhisa" sort="Sugiyama, Kazuhisa" uniqKey="Sugiyama K" first="Kazuhisa" last="Sugiyama">Kazuhisa Sugiyama</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641</wicri:regionArea>
<wicri:noRegion>920-8641</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Higashide, Tomomi" sort="Higashide, Tomomi" uniqKey="Higashide T" first="Tomomi" last="Higashide">Tomomi Higashide</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641</wicri:regionArea>
<wicri:noRegion>920-8641</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chihara, Etsuo" sort="Chihara, Etsuo" uniqKey="Chihara E" first="Etsuo" last="Chihara">Etsuo Chihara</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043</wicri:regionArea>
<wicri:noRegion>Kyoto 611-0043</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inoue, Kenji" sort="Inoue, Kenji" uniqKey="Inoue K" first="Kenji" last="Inoue">Kenji Inoue</name>
<affiliation wicri:level="3"><nlm:aff id="A41">Inouye Eye Hospital, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Inouye Eye Hospital, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ishiko, Satoshi" sort="Ishiko, Satoshi" uniqKey="Ishiko S" first="Satoshi" last="Ishiko">Satoshi Ishiko</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa</wicri:regionArea>
<wicri:noRegion>Asahikawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshida, Akitoshi" sort="Yoshida, Akitoshi" uniqKey="Yoshida A" first="Akitoshi" last="Yoshida">Akitoshi Yoshida</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Asahikawa Medical University, Asahikawa</wicri:regionArea>
<wicri:noRegion>Asahikawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanagi, Masahide" sort="Yanagi, Masahide" uniqKey="Yanagi M" first="Masahide" last="Yanagi">Masahide Yanagi</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kiuchi, Yoshiaki" sort="Kiuchi, Yoshiaki" uniqKey="Kiuchi Y" first="Yoshiaki" last="Kiuchi">Yoshiaki Kiuchi</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aihara, Makoto" sort="Aihara, Makoto" uniqKey="Aihara M" first="Makoto" last="Aihara">Makoto Aihara</name>
<affiliation wicri:level="3"><nlm:aff id="A45">Yotsuya Shirato Eye Clinic, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yotsuya Shirato Eye Clinic, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ohashi, Tsutomu" sort="Ohashi, Tsutomu" uniqKey="Ohashi T" first="Tsutomu" last="Ohashi">Tsutomu Ohashi</name>
<affiliation><nlm:aff id="A46">Ohashi eye center, Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</nlm:aff>
<wicri:noCountry code="subfield">Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sakurai, Toshiya" sort="Sakurai, Toshiya" uniqKey="Sakurai T" first="Toshiya" last="Sakurai">Toshiya Sakurai</name>
<affiliation><nlm:aff id="A47">Tane Memorial Eye Hospital, Osaka</nlm:aff>
<wicri:noCountry code="subfield">Osaka</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sugimoto, Takako" sort="Sugimoto, Takako" uniqKey="Sugimoto T" first="Takako" last="Sugimoto">Takako Sugimoto</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki</wicri:regionArea>
<wicri:noRegion>Miyazaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chuman, Hideki" sort="Chuman, Hideki" uniqKey="Chuman H" first="Hideki" last="Chuman">Hideki Chuman</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki</wicri:regionArea>
<wicri:noRegion>Miyazaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matsuda, Fumihiko" sort="Matsuda, Fumihiko" uniqKey="Matsuda F" first="Fumihiko" last="Matsuda">Fumihiko Matsuda</name>
<affiliation wicri:level="1"><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotoh, Norimoto" sort="Gotoh, Norimoto" uniqKey="Gotoh N" first="Norimoto" last="Gotoh">Norimoto Gotoh</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name>
<affiliation wicri:level="1"><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Astakhov, Sergei Y" sort="Astakhov, Sergei Y" uniqKey="Astakhov S" first="Sergei Y." last="Astakhov">Sergei Y. Astakhov</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Owaidhah, Ohoud" sort="Owaidhah, Ohoud" uniqKey="Owaidhah O" first="Ohoud" last="Owaidhah">Ohoud Owaidhah</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Jasim, Leyla" sort="Al Jasim, Leyla" uniqKey="Al Jasim L" first="Leyla" last="Al-Jasim">Leyla Al-Jasim</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Shahwan, Sami" sort="Al Shahwan, Sami" uniqKey="Al Shahwan S" first="Sami" last="Al Shahwan">Sami Al Shahwan</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fogarty, Rhys A" sort="Fogarty, Rhys A" uniqKey="Fogarty R" first="Rhys A." last="Fogarty">Rhys A. Fogarty</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name>
<affiliation wicri:level="1"><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld</wicri:regionArea>
<wicri:noRegion>Qld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yetkin, Yaz" sort="Yetkin, Yaz" uniqKey="Yetkin Y" first="Yaz" last="Yetkin">Yaz Yetkin</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir</wicri:regionArea>
<wicri:noRegion>Eskisehir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Uz, Cilingir" sort="O Uz, Cilingir" uniqKey="O Uz C" first="Çilingir" last="O Uz">Çilingir O Uz</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir</wicri:regionArea>
<wicri:noRegion>Eskisehir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanavi, Mozhgan Rezaei" sort="Kanavi, Mozhgan Rezaei" uniqKey="Kanavi M" first="Mozhgan Rezaei" last="Kanavi">Mozhgan Rezaei Kanavi</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Beni, Afsaneh Naderi" sort="Beni, Afsaneh Naderi" uniqKey="Beni A" first="Afsaneh Naderi" last="Beni">Afsaneh Naderi Beni</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yazdani, Shahin" sort="Yazdani, Shahin" uniqKey="Yazdani S" first="Shahin" last="Yazdani">Shahin Yazdani</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akopov, Evgeny L" sort="Akopov, Evgeny L" uniqKey="Akopov E" first="Evgeny L." last="Akopov">Evgeny L. Akopov</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Toh, Kai Yee" sort="Toh, Kai Yee" uniqKey="Toh K" first="Kai-Yee" last="Toh">Kai-Yee Toh</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Howell, Gareth R" sort="Howell, Gareth R" uniqKey="Howell G" first="Gareth R" last="Howell">Gareth R. Howell</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Orr, Andrew C" sort="Orr, Andrew C" uniqKey="Orr A" first="Andrew C." last="Orr">Andrew C. Orr</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goh, Yufen" sort="Goh, Yufen" uniqKey="Goh Y" first="Yufen" last="Goh">Yufen Goh</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Peh, Su Qin" sort="Peh, Su Qin" uniqKey="Peh S" first="Su Qin" last="Peh">Su Qin Peh</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kosior Jarecka, Ewa" sort="Kosior Jarecka, Ewa" uniqKey="Kosior Jarecka E" first="Ewa" last="Kosior-Jarecka">Ewa Kosior-Jarecka</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin</wicri:regionArea>
<wicri:noRegion>20-079 Lublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lukasik, Urszula" sort="Lukasik, Urszula" uniqKey="Lukasik U" first="Urszula" last="Lukasik">Urszula Lukasik</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin</wicri:regionArea>
<wicri:noRegion>20-079 Lublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krumbiegel, Mandy" sort="Krumbiegel, Mandy" uniqKey="Krumbiegel M" first="Mandy" last="Krumbiegel">Mandy Krumbiegel</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Medicine, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A53">Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta</wicri:regionArea>
<wicri:noRegion>Augusta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Medicine, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Duke University Eye Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rautenbach, Robyn M" sort="Rautenbach, Robyn M" uniqKey="Rautenbach R" first="Robyn M" last="Rautenbach">Robyn M. Rautenbach</name>
<affiliation wicri:level="1"><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name>
<affiliation wicri:level="1"><nlm:aff id="A55">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff>
<wicri:noCountry code="subfield">University of Tasmania</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="2"><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff>
<country>Australie</country>
<placeName><region type="state">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:cityArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff>
<country>Australie</country>
<placeName><region type="state">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:cityArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ziskind, Ari" sort="Ziskind, Ari" uniqKey="Ziskind A" first="Ari" last="Ziskind">Ari Ziskind</name>
<affiliation wicri:level="1"><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carmichael, Trevor" sort="Carmichael, Trevor" uniqKey="Carmichael T" first="Trevor" last="Carmichael">Trevor Carmichael</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg</wicri:regionArea>
<orgName type="university">Université du Witwatersrand</orgName>
<placeName><settlement type="city">Johannesbourg</settlement>
<region type="region" nuts="2">Gauteng</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramakrishnan, Rangappa" sort="Ramakrishnan, Rangappa" uniqKey="Ramakrishnan R" first="Rangappa" last="Ramakrishnan">Rangappa Ramakrishnan</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Narendran, Kalpana" sort="Narendran, Kalpana" uniqKey="Narendran K" first="Kalpana" last="Narendran">Kalpana Narendran</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Venkatesh, Rangaraj" sort="Venkatesh, Rangaraj" uniqKey="Venkatesh R" first="Rangaraj" last="Venkatesh">Rangaraj Venkatesh</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name>
<affiliation wicri:level="1"><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Peiquan" sort="Zhao, Peiquan" uniqKey="Zhao P" first="Peiquan" last="Zhao">Peiquan Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="A59">Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092</wicri:regionArea>
<wicri:noRegion>Shanghai 200092</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xueyi" sort="Chen, Xueyi" uniqKey="Chen X" first="Xueyi" last="Chen">Xueyi Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A60">Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region</wicri:regionArea>
<wicri:noRegion>Xinjiang Uygur Autonomous Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guadarrama Vallejo, Dalia" sort="Guadarrama Vallejo, Dalia" uniqKey="Guadarrama Vallejo D" first="Dalia" last="Guadarrama-Vallejo">Dalia Guadarrama-Vallejo</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Genetics Department, Institute of Ophthalmology “Conde de Valenciana”</wicri:regionArea>
<wicri:noRegion>Institute of Ophthalmology “Conde de Valenciana”</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Biochemistry Department, Faculty of Medicine, UNAM, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ho, Su Ling" sort="Ho, Su Ling" uniqKey="Ho S" first="Su-Ling" last="Ho">Su-Ling Ho</name>
<affiliation wicri:level="1"><nlm:aff id="A61">National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>National Healthcare Group Eye Institute, Tan Tock Seng Hospital</wicri:regionArea>
<wicri:noRegion>Tan Tock Seng Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Welge Luessen, Ulrich Christoph" sort="Welge Luessen, Ulrich Christoph" uniqKey="Welge Luessen U" first="Ulrich-Christoph" last="Welge-Luessen">Ulrich-Christoph Welge-Luessen</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mardin, Christian" sort="Mardin, Christian" uniqKey="Mardin C" first="Christian" last="Mardin">Christian Mardin</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schloetzer Schrehardt, Ursula" sort="Schloetzer Schrehardt, Ursula" uniqKey="Schloetzer Schrehardt U" first="Ursula" last="Schloetzer-Schrehardt">Ursula Schloetzer-Schrehardt</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hillmer, Axel M" sort="Hillmer, Axel M" uniqKey="Hillmer A" first="Axel M." last="Hillmer">Axel M. Hillmer</name>
<affiliation><nlm:aff id="A63">Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A66">Division of Medical Genetics, University Hospital, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Medical Genetics, University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A67">Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name>
<affiliation wicri:level="1"><nlm:aff id="A68">Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisschuh, Nicole" sort="Weisschuh, Nicole" uniqKey="Weisschuh N" first="Nicole" last="Weisschuh">Nicole Weisschuh</name>
<affiliation wicri:level="1"><nlm:aff id="A69">University Eye Hospital, Wuerzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Eye Hospital, Wuerzburg</wicri:regionArea>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shetty, Rohit" sort="Shetty, Rohit" uniqKey="Shetty R" first="Rohit" last="Shetty">Rohit Shetty</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010</wicri:regionArea>
<wicri:noRegion>Bangalore 560 010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghosh, Arkasubhra" sort="Ghosh, Arkasubhra" uniqKey="Ghosh A" first="Arkasubhra" last="Ghosh">Arkasubhra Ghosh</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A70">Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore</wicri:regionArea>
<wicri:noRegion>Bangalore</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A71">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld</wicri:regionArea>
<wicri:noRegion>Qld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lischinsky, Ignacio" sort="Lischinsky, Ignacio" uniqKey="Lischinsky I" first="Ignacio" last="Lischinsky">Ignacio Lischinsky</name>
<affiliation><nlm:aff id="A72">Centro Oftalmologico Lischinsky, Junin 692, Tucuman (4000) – Argentina</nlm:aff>
<wicri:noCountry code="subfield">Tucuman (4000) – Argentina</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Crowston, Jonathan G" sort="Crowston, Jonathan G" uniqKey="Crowston J" first="Jonathan G" last="Crowston">Jonathan G. Crowston</name>
<affiliation wicri:level="4"><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Coote, Michael" sort="Coote, Michael" uniqKey="Coote M" first="Michael" last="Coote">Michael Coote</name>
<affiliation wicri:level="4"><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name>
<affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="You, Qisheng" sort="You, Qisheng" uniqKey="You Q" first="Qisheng" last="You">Qisheng You</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vysochinskaya, Vera" sort="Vysochinskaya, Vera" uniqKey="Vysochinskaya V" first="Vera" last="Vysochinskaya">Vera Vysochinskaya</name>
<affiliation wicri:level="1"><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg</wicri:regionArea>
<wicri:noRegion>194021 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Founti, Panayiota" sort="Founti, Panayiota" uniqKey="Founti P" first="Panayiota" last="Founti">Panayiota Founti</name>
<affiliation wicri:level="1"><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chatzikyriakidou, Anthoula" sort="Chatzikyriakidou, Anthoula" uniqKey="Chatzikyriakidou A" first="Anthoula" last="Chatzikyriakidou">Anthoula Chatzikyriakidou</name>
<affiliation wicri:level="1"><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki</wicri:regionArea>
<wicri:noRegion>Aristotle University of Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambropoulos, Alexandros" sort="Lambropoulos, Alexandros" uniqKey="Lambropoulos A" first="Alexandros" last="Lambropoulos">Alexandros Lambropoulos</name>
<affiliation wicri:level="1"><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki</wicri:regionArea>
<wicri:noRegion>Aristotle University of Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anastasopoulos, Eleftherios" sort="Anastasopoulos, Eleftherios" uniqKey="Anastasopoulos E" first="Eleftherios" last="Anastasopoulos">Eleftherios Anastasopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coleman, Anne L" sort="Coleman, Anne L" uniqKey="Coleman A" first="Anne L" last="Coleman">Anne L. Coleman</name>
<affiliation wicri:level="2"><nlm:aff id="A77">Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wilson, M Roy" sort="Wilson, M Roy" uniqKey="Wilson M" first="M Roy" last="Wilson">M Roy Wilson</name>
<affiliation wicri:level="1"><nlm:aff id="A78">Wayne State University, Detroit, 48202, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Wayne State University, Detroit, 48202</wicri:regionArea>
<wicri:noRegion>48202</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhee, Douglas J" sort="Rhee, Douglas J" uniqKey="Rhee D" first="Douglas J" last="Rhee">Douglas J. Rhee</name>
<affiliation wicri:level="2"><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, Jae Hee" sort="Kang, Jae Hee" uniqKey="Kang J" first="Jae Hee" last="Kang">Jae Hee Kang</name>
<affiliation wicri:level="2"><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="May Bolchakova, Inna" sort="May Bolchakova, Inna" uniqKey="May Bolchakova I" first="Inna" last="May-Bolchakova">Inna May-Bolchakova</name>
<affiliation wicri:level="3"><nlm:aff id="A81">Ophthalmology Department, Military Hospital Begin, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ophthalmology Department, Military Hospital Begin, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heegaard, Steffen" sort="Heegaard, Steffen" uniqKey="Heegaard S" first="Steffen" last="Heegaard">Steffen Heegaard</name>
<affiliation wicri:level="3"><nlm:aff id="A82">Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A83">Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Ophthalmology, Glostrup University Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alward, Wallace L M" sort="Alward, Wallace L M" uniqKey="Alward W" first="Wallace L. M." last="Alward">Wallace L. M. Alward</name>
<affiliation wicri:level="4"><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stephen A. Wynn Institute for Vision Research, University of Iowa</wicri:regionArea>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff>
<orgName type="university">Université de l'Iowa</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name>
<affiliation wicri:level="1"><nlm:aff id="A86">Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:regionArea>
<wicri:noRegion>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:noRegion>
<wicri:noRegion>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:noRegion>
<wicri:noRegion>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liebmann, Jeffrey M" sort="Liebmann, Jeffrey M" uniqKey="Liebmann J" first="Jeffrey M" last="Liebmann">Jeffrey M. Liebmann</name>
<affiliation wicri:level="2"><nlm:aff id="A87">New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chowbay, Balram" sort="Chowbay, Balram" uniqKey="Chowbay B" first="Balram" last="Chowbay">Balram Chowbay</name>
<affiliation><nlm:aff id="A88">Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore</nlm:aff>
<wicri:noCountry code="subfield">National Cancer Centre of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Schaeffeler, Elke" sort="Schaeffeler, Elke" uniqKey="Schaeffeler E" first="Elke" last="Schaeffeler">Elke Schaeffeler</name>
<affiliation wicri:level="1"><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen</wicri:regionArea>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name>
<affiliation wicri:level="1"><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen</wicri:regionArea>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A90">Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Clinical Pharmacology, University Hospital, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A91">German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lerner, Fabian" sort="Lerner, Fabian" uniqKey="Lerner F" first="Fabian" last="Lerner">Fabian Lerner</name>
<affiliation><nlm:aff id="A92">Fundacion para el Estudio del Glaucoma, Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</nlm:aff>
<wicri:noCountry code="subfield">Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frezzotti, Paolo" sort="Frezzotti, Paolo" uniqKey="Frezzotti P" first="Paolo" last="Frezzotti">Paolo Frezzotti</name>
<affiliation wicri:level="1"><nlm:aff id="A93">Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgery, Section of Ophthalmology, University of Siena, Siena</wicri:regionArea>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fingert, John H" sort="Fingert, John H" uniqKey="Fingert J" first="John H." last="Fingert">John H. Fingert</name>
<affiliation wicri:level="4"><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stephen A. Wynn Institute for Vision Research, University of Iowa</wicri:regionArea>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff>
<orgName type="university">Université de l'Iowa</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Inatani, Masaru" sort="Inatani, Masaru" uniqKey="Inatani M" first="Masaru" last="Inatani">Masaru Inatani</name>
<affiliation wicri:level="1"><nlm:aff id="A94">Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193</wicri:regionArea>
<wicri:noRegion>910-1193</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reis, Andre" sort="Reis, Andre" uniqKey="Reis A" first="André" last="Reis">André Reis</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Edward, Deepak P" sort="Edward, Deepak P" uniqKey="Edward D" first="Deepak P." last="Edward">Deepak P. Edward</name>
<affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A95">Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name>
<affiliation wicri:level="2"><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubota, Toshiaki" sort="Kubota, Toshiaki" uniqKey="Kubota T" first="Toshiaki" last="Kubota">Toshiaki Kubota</name>
<affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff>
<wicri:noCountry code="subfield">Oita University Faculty of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name>
<affiliation wicri:level="2"><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasutto, Francesca" sort="Pasutto, Francesca" uniqKey="Pasutto F" first="Francesca" last="Pasutto">Francesca Pasutto</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Topouzis, Fotis" sort="Topouzis, Fotis" uniqKey="Topouzis F" first="Fotis" last="Topouzis">Fotis Topouzis</name>
<affiliation wicri:level="1"><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dubina, Michael" sort="Dubina, Michael" uniqKey="Dubina M" first="Michael" last="Dubina">Michael Dubina</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg</wicri:regionArea>
<wicri:noRegion>194021 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name>
<affiliation wicri:level="1"><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="John, Simon W M" sort="John, Simon W M" uniqKey="John S" first="Simon W. M." last="John">Simon W. M. John</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name>
<affiliation wicri:level="2"><nlm:aff id="A96">Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Duke University Eye Center, Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Medicine, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A common variant mapping to <italic>CACNA1A</italic>
 is associated with susceptibility to Exfoliation syndrome</title>
<author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name>
<affiliation><nlm:aff id="A4">Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066 Japan</nlm:aff>
<wicri:noCountry code="subfield">Miyazaki 883-0066 Japan</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka</wicri:regionArea>
<wicri:noRegion>Fukuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name>
<affiliation><nlm:aff id="A5">Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki, Japan 857-0016</nlm:aff>
<wicri:noCountry code="subfield">Japan 857-0016</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Duke University Eye Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Haripriya, Aravind" sort="Haripriya, Aravind" uniqKey="Haripriya A" first="Aravind" last="Haripriya">Aravind Haripriya</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nakano, Satoko" sort="Nakano, Satoko" uniqKey="Nakano S" first="Satoko" last="Nakano">Satoko Nakano</name>
<affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff>
<wicri:noCountry code="subfield">Oita University Faculty of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Uebe, Steffen" sort="Uebe, Steffen" uniqKey="Uebe S" first="Steffen" last="Uebe">Steffen Uebe</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harder, Jeffrey M" sort="Harder, Jeffrey M" uniqKey="Harder J" first="Jeffrey M." last="Harder">Jeffrey M. Harder</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff>
<wicri:noCountry code="subfield">University of Tasmania</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Astakhov, Yury S" sort="Astakhov, Yury S" uniqKey="Astakhov Y" first="Yury S." last="Astakhov">Yury S. Astakhov</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zenteno, Juan C" sort="Zenteno, Juan C" uniqKey="Zenteno J" first="Juan C." last="Zenteno">Juan C. Zenteno</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Genetics Department, Institute of Ophthalmology “Conde de Valenciana”</wicri:regionArea>
<wicri:noRegion>Institute of Ophthalmology “Conde de Valenciana”</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Biochemistry Department, Faculty of Medicine, UNAM, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nilgun, Yildirim" sort="Nilgun, Yildirim" uniqKey="Nilgun Y" first="Yildirim" last="Nilgün">Yildirim Nilgün</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir</wicri:regionArea>
<wicri:noRegion>Eskisehir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zarnowski, Tomasz" sort="Zarnowski, Tomasz" uniqKey="Zarnowski T" first="Tomasz" last="Zarnowski">Tomasz Zarnowski</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin</wicri:regionArea>
<wicri:noRegion>20-079 Lublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pakravan, Mohammad" sort="Pakravan, Mohammad" uniqKey="Pakravan M" first="Mohammad" last="Pakravan">Mohammad Pakravan</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Safieh, Leen Abu" sort="Safieh, Leen Abu" uniqKey="Safieh L" first="Leen Abu" last="Safieh">Leen Abu Safieh</name>
<affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Susan" sort="Williams, Susan" uniqKey="Williams S" first="Susan" last="Williams">Susan Williams</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg</wicri:regionArea>
<orgName type="university">Université du Witwatersrand</orgName>
<placeName><settlement type="city">Johannesbourg</settlement>
<region type="region" nuts="2">Gauteng</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paoli, Daniela" sort="Paoli, Daniela" uniqKey="Paoli D" first="Daniela" last="Paoli">Daniela Paoli</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Ophthalmology, Monfalcone Hospital, Gorizia</wicri:regionArea>
<wicri:noRegion>Gorizia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schlottmann, Patricio G" sort="Schlottmann, Patricio G" uniqKey="Schlottmann P" first="Patricio G" last="Schlottmann">Patricio G. Schlottmann</name>
<affiliation><nlm:aff id="A27">Organización Médica de Investigación, Uruguay 725 – PB, Buenos Aires (C1015ABO) Argentina</nlm:aff>
<wicri:noCountry code="subfield">Buenos Aires (C1015ABO) Argentina</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Huang, Lulin" sort="Huang, Lulin" uniqKey="Huang L" first="Lulin" last="Huang">Lulin Huang</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sim, Kar Seng" sort="Sim, Kar Seng" uniqKey="Sim K" first="Kar Seng" last="Sim">Kar Seng Sim</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kumar, Rajesh S" sort="Kumar, Rajesh S" uniqKey="Kumar R" first="Rajesh S" last="Kumar">Rajesh S. Kumar</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010</wicri:regionArea>
<wicri:noRegion>Bangalore 560 010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manabe, Shin Ichi" sort="Manabe, Shin Ichi" uniqKey="Manabe S" first="Shin-Ichi" last="Manabe">Shin-Ichi Manabe</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka</wicri:regionArea>
<wicri:noRegion>Fukuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayashi, Ken" sort="Hayashi, Ken" uniqKey="Hayashi K" first="Ken" last="Hayashi">Ken Hayashi</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka</wicri:regionArea>
<wicri:noRegion>Fukuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kazama, Shigeyasu" sort="Kazama, Shigeyasu" uniqKey="Kazama S" first="Shigeyasu" last="Kazama">Shigeyasu Kazama</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035,Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Shinjo Eye Clinic, 889-1,Mego, Simokitakatamachi, Miyazaki-shi, Miyazaki 880-0035</wicri:regionArea>
<wicri:noRegion>Miyazaki 880-0035</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ideta, Ryuichi" sort="Ideta, Ryuichi" uniqKey="Ideta R" first="Ryuichi" last="Ideta">Ryuichi Ideta</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Ideta Eye Hospital, Kumamoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Ideta Eye Hospital, Kumamoto</wicri:regionArea>
<wicri:noRegion>Kumamoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mori, Yosai" sort="Mori, Yosai" uniqKey="Mori Y" first="Yosai" last="Mori">Yosai Mori</name>
<affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff>
<wicri:noCountry code="subfield">Miyazaki 885-0051 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Miyata, Kazunori" sort="Miyata, Kazunori" uniqKey="Miyata K" first="Kazunori" last="Miyata">Kazunori Miyata</name>
<affiliation><nlm:aff id="A37">Miyata Eye Hospital, 6-3, Kurahara, Miyakonojo, Miyazaki 885-0051 Japan</nlm:aff>
<wicri:noCountry code="subfield">Miyazaki 885-0051 Japan</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki</wicri:regionArea>
<wicri:noRegion>Miyazaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sugiyama, Kazuhisa" sort="Sugiyama, Kazuhisa" uniqKey="Sugiyama K" first="Kazuhisa" last="Sugiyama">Kazuhisa Sugiyama</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641</wicri:regionArea>
<wicri:noRegion>920-8641</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Higashide, Tomomi" sort="Higashide, Tomomi" uniqKey="Higashide T" first="Tomomi" last="Higashide">Tomomi Higashide</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641</wicri:regionArea>
<wicri:noRegion>920-8641</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chihara, Etsuo" sort="Chihara, Etsuo" uniqKey="Chihara E" first="Etsuo" last="Chihara">Etsuo Chihara</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Uji, Kyoto 611-0043</wicri:regionArea>
<wicri:noRegion>Kyoto 611-0043</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inoue, Kenji" sort="Inoue, Kenji" uniqKey="Inoue K" first="Kenji" last="Inoue">Kenji Inoue</name>
<affiliation wicri:level="3"><nlm:aff id="A41">Inouye Eye Hospital, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Inouye Eye Hospital, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ishiko, Satoshi" sort="Ishiko, Satoshi" uniqKey="Ishiko S" first="Satoshi" last="Ishiko">Satoshi Ishiko</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa</wicri:regionArea>
<wicri:noRegion>Asahikawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshida, Akitoshi" sort="Yoshida, Akitoshi" uniqKey="Yoshida A" first="Akitoshi" last="Yoshida">Akitoshi Yoshida</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Asahikawa Medical University, Asahikawa</wicri:regionArea>
<wicri:noRegion>Asahikawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanagi, Masahide" sort="Yanagi, Masahide" uniqKey="Yanagi M" first="Masahide" last="Yanagi">Masahide Yanagi</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kiuchi, Yoshiaki" sort="Kiuchi, Yoshiaki" uniqKey="Kiuchi Y" first="Yoshiaki" last="Kiuchi">Yoshiaki Kiuchi</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aihara, Makoto" sort="Aihara, Makoto" uniqKey="Aihara M" first="Makoto" last="Aihara">Makoto Aihara</name>
<affiliation wicri:level="3"><nlm:aff id="A45">Yotsuya Shirato Eye Clinic, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yotsuya Shirato Eye Clinic, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ohashi, Tsutomu" sort="Ohashi, Tsutomu" uniqKey="Ohashi T" first="Tsutomu" last="Ohashi">Tsutomu Ohashi</name>
<affiliation><nlm:aff id="A46">Ohashi eye center, Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</nlm:aff>
<wicri:noCountry code="subfield">Kita1-1 Hondori6 Shiroishi-ku Sapporo 003-0027 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sakurai, Toshiya" sort="Sakurai, Toshiya" uniqKey="Sakurai T" first="Toshiya" last="Sakurai">Toshiya Sakurai</name>
<affiliation><nlm:aff id="A47">Tane Memorial Eye Hospital, Osaka</nlm:aff>
<wicri:noCountry code="subfield">Osaka</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sugimoto, Takako" sort="Sugimoto, Takako" uniqKey="Sugimoto T" first="Takako" last="Sugimoto">Takako Sugimoto</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki</wicri:regionArea>
<wicri:noRegion>Miyazaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chuman, Hideki" sort="Chuman, Hideki" uniqKey="Chuman H" first="Hideki" last="Chuman">Hideki Chuman</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki</wicri:regionArea>
<wicri:noRegion>Miyazaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matsuda, Fumihiko" sort="Matsuda, Fumihiko" uniqKey="Matsuda F" first="Fumihiko" last="Matsuda">Fumihiko Matsuda</name>
<affiliation wicri:level="1"><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotoh, Norimoto" sort="Gotoh, Norimoto" uniqKey="Gotoh N" first="Norimoto" last="Gotoh">Norimoto Gotoh</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name>
<affiliation wicri:level="1"><nlm:aff id="A48">Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Astakhov, Sergei Y" sort="Astakhov, Sergei Y" uniqKey="Astakhov S" first="Sergei Y." last="Astakhov">Sergei Y. Astakhov</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Owaidhah, Ohoud" sort="Owaidhah, Ohoud" uniqKey="Owaidhah O" first="Ohoud" last="Owaidhah">Ohoud Owaidhah</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Jasim, Leyla" sort="Al Jasim, Leyla" uniqKey="Al Jasim L" first="Leyla" last="Al-Jasim">Leyla Al-Jasim</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Shahwan, Sami" sort="Al Shahwan, Sami" uniqKey="Al Shahwan S" first="Sami" last="Al Shahwan">Sami Al Shahwan</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fogarty, Rhys A" sort="Fogarty, Rhys A" uniqKey="Fogarty R" first="Rhys A." last="Fogarty">Rhys A. Fogarty</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name>
<affiliation wicri:level="1"><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld</wicri:regionArea>
<wicri:noRegion>Qld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yetkin, Yaz" sort="Yetkin, Yaz" uniqKey="Yetkin Y" first="Yaz" last="Yetkin">Yaz Yetkin</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir</wicri:regionArea>
<wicri:noRegion>Eskisehir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Uz, Cilingir" sort="O Uz, Cilingir" uniqKey="O Uz C" first="Çilingir" last="O Uz">Çilingir O Uz</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir</wicri:regionArea>
<wicri:noRegion>Eskisehir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanavi, Mozhgan Rezaei" sort="Kanavi, Mozhgan Rezaei" uniqKey="Kanavi M" first="Mozhgan Rezaei" last="Kanavi">Mozhgan Rezaei Kanavi</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Beni, Afsaneh Naderi" sort="Beni, Afsaneh Naderi" uniqKey="Beni A" first="Afsaneh Naderi" last="Beni">Afsaneh Naderi Beni</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yazdani, Shahin" sort="Yazdani, Shahin" uniqKey="Yazdani S" first="Shahin" last="Yazdani">Shahin Yazdani</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Ophthalmic Research Center, Ophthalmology department, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akopov, Evgeny L" sort="Akopov, Evgeny L" uniqKey="Akopov E" first="Evgeny L." last="Akopov">Evgeny L. Akopov</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Toh, Kai Yee" sort="Toh, Kai Yee" uniqKey="Toh K" first="Kai-Yee" last="Toh">Kai-Yee Toh</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Howell, Gareth R" sort="Howell, Gareth R" uniqKey="Howell G" first="Gareth R" last="Howell">Gareth R. Howell</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Orr, Andrew C" sort="Orr, Andrew C" uniqKey="Orr A" first="Andrew C." last="Orr">Andrew C. Orr</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goh, Yufen" sort="Goh, Yufen" uniqKey="Goh Y" first="Yufen" last="Goh">Yufen Goh</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Peh, Su Qin" sort="Peh, Su Qin" uniqKey="Peh S" first="Su Qin" last="Peh">Su Qin Peh</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kosior Jarecka, Ewa" sort="Kosior Jarecka, Ewa" uniqKey="Kosior Jarecka E" first="Ewa" last="Kosior-Jarecka">Ewa Kosior-Jarecka</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin</wicri:regionArea>
<wicri:noRegion>20-079 Lublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lukasik, Urszula" sort="Lukasik, Urszula" uniqKey="Lukasik U" first="Urszula" last="Lukasik">Urszula Lukasik</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland, Chmielna 1, 20-079 Lublin</wicri:regionArea>
<wicri:noRegion>20-079 Lublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krumbiegel, Mandy" sort="Krumbiegel, Mandy" uniqKey="Krumbiegel M" first="Mandy" last="Krumbiegel">Mandy Krumbiegel</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Medicine, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A53">Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta</wicri:regionArea>
<wicri:noRegion>Augusta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Medicine, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Duke University Eye Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rautenbach, Robyn M" sort="Rautenbach, Robyn M" uniqKey="Rautenbach R" first="Robyn M" last="Rautenbach">Robyn M. Rautenbach</name>
<affiliation wicri:level="1"><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name>
<affiliation wicri:level="1"><nlm:aff id="A55">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<affiliation><nlm:aff id="A13">Menzies Institute for Medical Research, University of Tasmania</nlm:aff>
<wicri:noCountry code="subfield">University of Tasmania</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="2"><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff>
<country>Australie</country>
<placeName><region type="state">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:cityArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A57">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW Australia</nlm:aff>
<country>Australie</country>
<placeName><region type="state">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:cityArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ziskind, Ari" sort="Ziskind, Ari" uniqKey="Ziskind A" first="Ari" last="Ziskind">Ari Ziskind</name>
<affiliation wicri:level="1"><nlm:aff id="A54">Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carmichael, Trevor" sort="Carmichael, Trevor" uniqKey="Carmichael T" first="Trevor" last="Carmichael">Trevor Carmichael</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg</wicri:regionArea>
<orgName type="university">Université du Witwatersrand</orgName>
<placeName><settlement type="city">Johannesbourg</settlement>
<region type="region" nuts="2">Gauteng</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramakrishnan, Rangappa" sort="Ramakrishnan, Rangappa" uniqKey="Ramakrishnan R" first="Rangappa" last="Ramakrishnan">Rangappa Ramakrishnan</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Narendran, Kalpana" sort="Narendran, Kalpana" uniqKey="Narendran K" first="Kalpana" last="Narendran">Kalpana Narendran</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Venkatesh, Rangaraj" sort="Venkatesh, Rangaraj" uniqKey="Venkatesh R" first="Rangaraj" last="Venkatesh">Rangaraj Venkatesh</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name>
<affiliation wicri:level="1"><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Peiquan" sort="Zhao, Peiquan" uniqKey="Zhao P" first="Peiquan" last="Zhao">Peiquan Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="A59">Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092</wicri:regionArea>
<wicri:noRegion>Shanghai 200092</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xueyi" sort="Chen, Xueyi" uniqKey="Chen X" first="Xueyi" last="Chen">Xueyi Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A60">Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region</wicri:regionArea>
<wicri:noRegion>Xinjiang Uygur Autonomous Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guadarrama Vallejo, Dalia" sort="Guadarrama Vallejo, Dalia" uniqKey="Guadarrama Vallejo D" first="Dalia" last="Guadarrama-Vallejo">Dalia Guadarrama-Vallejo</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Genetics Department, Institute of Ophthalmology “Conde de Valenciana”, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Genetics Department, Institute of Ophthalmology “Conde de Valenciana”</wicri:regionArea>
<wicri:noRegion>Institute of Ophthalmology “Conde de Valenciana”</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Biochemistry Department, Faculty of Medicine, UNAM, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ho, Su Ling" sort="Ho, Su Ling" uniqKey="Ho S" first="Su-Ling" last="Ho">Su-Ling Ho</name>
<affiliation wicri:level="1"><nlm:aff id="A61">National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>National Healthcare Group Eye Institute, Tan Tock Seng Hospital</wicri:regionArea>
<wicri:noRegion>Tan Tock Seng Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Welge Luessen, Ulrich Christoph" sort="Welge Luessen, Ulrich Christoph" uniqKey="Welge Luessen U" first="Ulrich-Christoph" last="Welge-Luessen">Ulrich-Christoph Welge-Luessen</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mardin, Christian" sort="Mardin, Christian" uniqKey="Mardin C" first="Christian" last="Mardin">Christian Mardin</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schloetzer Schrehardt, Ursula" sort="Schloetzer Schrehardt, Ursula" uniqKey="Schloetzer Schrehardt U" first="Ursula" last="Schloetzer-Schrehardt">Ursula Schloetzer-Schrehardt</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hillmer, Axel M" sort="Hillmer, Axel M" uniqKey="Hillmer A" first="Axel M." last="Hillmer">Axel M. Hillmer</name>
<affiliation><nlm:aff id="A63">Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A66">Division of Medical Genetics, University Hospital, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Medical Genetics, University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A67">Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name>
<affiliation wicri:level="1"><nlm:aff id="A68">Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A65">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisschuh, Nicole" sort="Weisschuh, Nicole" uniqKey="Weisschuh N" first="Nicole" last="Weisschuh">Nicole Weisschuh</name>
<affiliation wicri:level="1"><nlm:aff id="A69">University Eye Hospital, Wuerzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Eye Hospital, Wuerzburg</wicri:regionArea>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shetty, Rohit" sort="Shetty, Rohit" uniqKey="Shetty R" first="Rohit" last="Shetty">Rohit Shetty</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Glaucoma services, Narayana Nethralaya Eye Hospital, 121/C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010</wicri:regionArea>
<wicri:noRegion>Bangalore 560 010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghosh, Arkasubhra" sort="Ghosh, Arkasubhra" uniqKey="Ghosh A" first="Arkasubhra" last="Ghosh">Arkasubhra Ghosh</name>
<affiliation><nlm:aff id="A1">Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751</nlm:aff>
<wicri:noCountry code="subfield">Singapore 168751</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A70">Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Genes, Repair and Regeneration in Ophthalmic Workstation Research Lab, Narayana Nethralaya Foundation, Bangalore</wicri:regionArea>
<wicri:noRegion>Bangalore</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A71">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="A50">University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld</wicri:regionArea>
<wicri:noRegion>Qld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lischinsky, Ignacio" sort="Lischinsky, Ignacio" uniqKey="Lischinsky I" first="Ignacio" last="Lischinsky">Ignacio Lischinsky</name>
<affiliation><nlm:aff id="A72">Centro Oftalmologico Lischinsky, Junin 692, Tucuman (4000) – Argentina</nlm:aff>
<wicri:noCountry code="subfield">Tucuman (4000) – Argentina</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Crowston, Jonathan G" sort="Crowston, Jonathan G" uniqKey="Crowston J" first="Jonathan G" last="Crowston">Jonathan G. Crowston</name>
<affiliation wicri:level="4"><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Coote, Michael" sort="Coote, Michael" uniqKey="Coote M" first="Michael" last="Coote">Michael Coote</name>
<affiliation wicri:level="4"><nlm:aff id="A56">Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A73">Department of Ophthalmology, University of Melbourne</nlm:aff>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name>
<affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="You, Qisheng" sort="You, Qisheng" uniqKey="You Q" first="Qisheng" last="You">Qisheng You</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vysochinskaya, Vera" sort="Vysochinskaya, Vera" uniqKey="Vysochinskaya V" first="Vera" last="Vysochinskaya">Vera Vysochinskaya</name>
<affiliation wicri:level="1"><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg</wicri:regionArea>
<wicri:noRegion>194021 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Founti, Panayiota" sort="Founti, Panayiota" uniqKey="Founti P" first="Panayiota" last="Founti">Panayiota Founti</name>
<affiliation wicri:level="1"><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chatzikyriakidou, Anthoula" sort="Chatzikyriakidou, Anthoula" uniqKey="Chatzikyriakidou A" first="Anthoula" last="Chatzikyriakidou">Anthoula Chatzikyriakidou</name>
<affiliation wicri:level="1"><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki</wicri:regionArea>
<wicri:noRegion>Aristotle University of Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambropoulos, Alexandros" sort="Lambropoulos, Alexandros" uniqKey="Lambropoulos A" first="Alexandros" last="Lambropoulos">Alexandros Lambropoulos</name>
<affiliation wicri:level="1"><nlm:aff id="A76">Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki</wicri:regionArea>
<wicri:noRegion>Aristotle University of Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anastasopoulos, Eleftherios" sort="Anastasopoulos, Eleftherios" uniqKey="Anastasopoulos E" first="Eleftherios" last="Anastasopoulos">Eleftherios Anastasopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coleman, Anne L" sort="Coleman, Anne L" uniqKey="Coleman A" first="Anne L" last="Coleman">Anne L. Coleman</name>
<affiliation wicri:level="2"><nlm:aff id="A77">Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wilson, M Roy" sort="Wilson, M Roy" uniqKey="Wilson M" first="M Roy" last="Wilson">M Roy Wilson</name>
<affiliation wicri:level="1"><nlm:aff id="A78">Wayne State University, Detroit, 48202, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Wayne State University, Detroit, 48202</wicri:regionArea>
<wicri:noRegion>48202</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhee, Douglas J" sort="Rhee, Douglas J" uniqKey="Rhee D" first="Douglas J" last="Rhee">Douglas J. Rhee</name>
<affiliation wicri:level="2"><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, Jae Hee" sort="Kang, Jae Hee" uniqKey="Kang J" first="Jae Hee" last="Kang">Jae Hee Kang</name>
<affiliation wicri:level="2"><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="May Bolchakova, Inna" sort="May Bolchakova, Inna" uniqKey="May Bolchakova I" first="Inna" last="May-Bolchakova">Inna May-Bolchakova</name>
<affiliation wicri:level="3"><nlm:aff id="A81">Ophthalmology Department, Military Hospital Begin, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ophthalmology Department, Military Hospital Begin, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heegaard, Steffen" sort="Heegaard, Steffen" uniqKey="Heegaard S" first="Steffen" last="Heegaard">Steffen Heegaard</name>
<affiliation wicri:level="3"><nlm:aff id="A82">Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A83">Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Ophthalmology, Glostrup University Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alward, Wallace L M" sort="Alward, Wallace L M" uniqKey="Alward W" first="Wallace L. M." last="Alward">Wallace L. M. Alward</name>
<affiliation wicri:level="4"><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stephen A. Wynn Institute for Vision Research, University of Iowa</wicri:regionArea>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff>
<orgName type="university">Université de l'Iowa</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name>
<affiliation wicri:level="1"><nlm:aff id="A86">Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:regionArea>
<wicri:noRegion>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:noRegion>
<wicri:noRegion>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:noRegion>
<wicri:noRegion>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liebmann, Jeffrey M" sort="Liebmann, Jeffrey M" uniqKey="Liebmann J" first="Jeffrey M" last="Liebmann">Jeffrey M. Liebmann</name>
<affiliation wicri:level="2"><nlm:aff id="A87">New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>New York University School of Medicine; Manhattan Eye, Ear and Throat Hospital</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chowbay, Balram" sort="Chowbay, Balram" uniqKey="Chowbay B" first="Balram" last="Chowbay">Balram Chowbay</name>
<affiliation><nlm:aff id="A88">Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore</nlm:aff>
<wicri:noCountry code="subfield">National Cancer Centre of Singapore</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Schaeffeler, Elke" sort="Schaeffeler, Elke" uniqKey="Schaeffeler E" first="Elke" last="Schaeffeler">Elke Schaeffeler</name>
<affiliation wicri:level="1"><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen</wicri:regionArea>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name>
<affiliation wicri:level="1"><nlm:aff id="A89">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tuebingen</wicri:regionArea>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
<wicri:noRegion>and University Tuebingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A90">Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Clinical Pharmacology, University Hospital, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A91">German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lerner, Fabian" sort="Lerner, Fabian" uniqKey="Lerner F" first="Fabian" last="Lerner">Fabian Lerner</name>
<affiliation><nlm:aff id="A92">Fundacion para el Estudio del Glaucoma, Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</nlm:aff>
<wicri:noCountry code="subfield">Marcelo T de Alvear 2010 - 2A Buenos Aires (C1122AAF) Argentina</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A29">School of Medicine, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frezzotti, Paolo" sort="Frezzotti, Paolo" uniqKey="Frezzotti P" first="Paolo" last="Frezzotti">Paolo Frezzotti</name>
<affiliation wicri:level="1"><nlm:aff id="A93">Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgery, Section of Ophthalmology, University of Siena, Siena</wicri:regionArea>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fingert, John H" sort="Fingert, John H" uniqKey="Fingert J" first="John H." last="Fingert">John H. Fingert</name>
<affiliation wicri:level="4"><nlm:aff id="A84">Stephen A. Wynn Institute for Vision Research, University of Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stephen A. Wynn Institute for Vision Research, University of Iowa</wicri:regionArea>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A85">Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City</nlm:aff>
<orgName type="university">Université de l'Iowa</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Inatani, Masaru" sort="Inatani, Masaru" uniqKey="Inatani M" first="Masaru" last="Inatani">Masaru Inatani</name>
<affiliation wicri:level="1"><nlm:aff id="A94">Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193</wicri:regionArea>
<wicri:noRegion>910-1193</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reis, Andre" sort="Reis, Andre" uniqKey="Reis A" first="André" last="Reis">André Reis</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Edward, Deepak P" sort="Edward, Deepak P" uniqKey="Edward D" first="Deepak P." last="Edward">Deepak P. Edward</name>
<affiliation><nlm:aff id="A22">King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A95">Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name>
<affiliation wicri:level="2"><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A80">Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubota, Toshiaki" sort="Kubota, Toshiaki" uniqKey="Kubota T" first="Toshiaki" last="Kubota">Toshiaki Kubota</name>
<affiliation><nlm:aff id="A9">Department of Ophthalmology, Oita University Faculty of Medicine</nlm:aff>
<wicri:noCountry code="subfield">Oita University Faculty of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name>
<affiliation wicri:level="2"><nlm:aff id="A79">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasutto, Francesca" sort="Pasutto, Francesca" uniqKey="Pasutto F" first="Francesca" last="Pasutto">Francesca Pasutto</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:regionArea>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
<wicri:noRegion>Friedrich-Alexander-Universität Erlangen-Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Topouzis, Fotis" sort="Topouzis, Fotis" uniqKey="Topouzis F" first="Fotis" last="Topouzis">Fotis Topouzis</name>
<affiliation wicri:level="1"><nlm:aff id="A75">Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dubina, Michael" sort="Dubina, Michael" uniqKey="Dubina M" first="Michael" last="Dubina">Michael Dubina</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, 6/8 L’va Tolstogo Street, 197022 St. Petersburg</wicri:regionArea>
<wicri:noRegion>197022 St. Petersburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A74">St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>St. Petersburg Academic University, 8/3 Klopina Street, 194021 St. Petersburg</wicri:regionArea>
<wicri:noRegion>194021 St. Petersburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Ophthalmology, Flinders University, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name>
<affiliation wicri:level="1"><nlm:aff id="A58">Department of Genetics, Aravind Medical Research Foundation, Madurai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai</wicri:regionArea>
<wicri:noRegion>Madurai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="John, Simon W M" sort="John, Simon W M" uniqKey="John S" first="Simon W. M." last="John">Simon W. M. John</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>The Howard Hughes Medical Institute, the Jackson Laboratory 600 Main Street, Bar Harbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name>
<affiliation wicri:level="2"><nlm:aff id="A96">Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States of America</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Ophthalmology, Duke University Eye Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Duke University Eye Center, Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A52">Department of Medicine, Duke University Medical Center, Durham, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Medicine, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</nlm:aff>
<country>Singapour</country>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation><nlm:aff id="A7">Division of Human Genetics, Genome Institute of Singapore</nlm:aff>
<wicri:noCountry code="subfield">Genome Institute of Singapore</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Asian Continental Ancestry Group (genetics)</term>
<term>Asian Continental Ancestry Group (statistics & numerical data)</term>
<term>Calcium Channels (genetics)</term>
<term>Case-Control Studies</term>
<term>Chromosome Mapping</term>
<term>Exfoliation Syndrome (epidemiology)</term>
<term>Exfoliation Syndrome (genetics)</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Glaucoma, Open-Angle (epidemiology)</term>
<term>Glaucoma, Open-Angle (genetics)</term>
<term>HEK293 Cells</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Japan (epidemiology)</term>
<term>MCF-7 Cells</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Tumor Cells, Cultured</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Canaux calciques (génétique)</term>
<term>Cartographie chromosomique</term>
<term>Cellules HEK293</term>
<term>Cellules HeLa</term>
<term>Cellules MCF-7</term>
<term>Cellules cancéreuses en culture</term>
<term>Glaucome capsulaire (génétique)</term>
<term>Glaucome capsulaire (épidémiologie)</term>
<term>Glaucome à angle ouvert (génétique)</term>
<term>Glaucome à angle ouvert (épidémiologie)</term>
<term>Humains</term>
<term>Japon (épidémiologie)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine asiatique ()</term>
<term>Population d'origine asiatique (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium Channels</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Japan</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Exfoliation Syndrome</term>
<term>Glaucoma, Open-Angle</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term>
<term>Exfoliation Syndrome</term>
<term>Glaucoma, Open-Angle</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Canaux calciques</term>
<term>Glaucome capsulaire</term>
<term>Glaucome à angle ouvert</term>
<term>Population d'origine asiatique</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Asian Continental Ancestry Group</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Glaucome capsulaire</term>
<term>Glaucome à angle ouvert</term>
<term>Japon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Case-Control Studies</term>
<term>Chromosome Mapping</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>HEK293 Cells</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>MCF-7 Cells</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Tumor Cells, Cultured</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cartographie chromosomique</term>
<term>Cellules HEK293</term>
<term>Cellules HeLa</term>
<term>Cellules MCF-7</term>
<term>Cellules cancéreuses en culture</term>
<term>Humains</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine asiatique</term>
<term>Prédisposition génétique à une maladie</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Exfoliation syndrome (XFS) is the commonest recognizable cause of open angle glaucoma world-wide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) on 1,484 patients and 1,188 controls from Japan, and followed up the most significant findings on a further 6,901 patients and 20,727 controls from 17 countries across 6 continents. We discovered a significant association between a new locus (<italic>CACNA1A</italic>
 rs4926244) and increased susceptibility to XFS (Odds ratio [OR] = 1.16, <italic>P</italic>
 = 3.36 × 10<sup>−11</sup>
). Although overwhelming association at the <italic>LOXL1</italic>
 locus was confirmed, the key SNP marker (<italic>LOXL1</italic>
 rs4886776) demonstrated allelic reversal depending on ethnic grouping (In Japanese: OR<sub>A-allele</sub>
= 9.87, <italic>P</italic>
 = 2.13 × 10<sup>−217</sup>
; In non-Japanese: OR<sub>A-allele</sub>
= 0.49, <italic>P</italic>
 = 2.35 × 10<sup>−31</sup>
). Our findings represent the first genetic locus outside of <italic>LOXL1</italic>
 which surpasses genome-wide significance for XFS, and provides insight into the biology and pathogenesis of the disease.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
<li>Allemagne</li>
<li>Arabie saoudite</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>France</li>
<li>Grèce</li>
<li>Géorgie (pays)</li>
<li>Inde</li>
<li>Iran</li>
<li>Italie</li>
<li>Japon</li>
<li>Mexique</li>
<li>Pologne</li>
<li>Russie</li>
<li>République populaire de Chine</li>
<li>Singapour</li>
<li>Suisse</li>
<li>Turquie</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Californie</li>
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<li>District de Cologne</li>
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<li>District de Tübingen</li>
<li>Floride</li>
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<li>Iowa</li>
<li>Maine (État)</li>
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<li>Massachusetts</li>
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<li>Rhénanie-du-Nord-Westphalie</li>
<li>Région de Kantō</li>
<li>Victoria (État)</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
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<li>Copenhague</li>
<li>Heidelberg</li>
<li>Iowa City</li>
<li>Johannesbourg</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Pékin</li>
<li>Tokyo</li>
<li>Tübingen</li>
</settlement>
<orgName><li>Université de Melbourne</li>
<li>Université de l'Iowa</li>
<li>Université du Witwatersrand</li>
<li>Université nationale de Singapour</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name>
<name sortKey="Chowbay, Balram" sort="Chowbay, Balram" uniqKey="Chowbay B" first="Balram" last="Chowbay">Balram Chowbay</name>
<name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name>
<name sortKey="Goh, Yufen" sort="Goh, Yufen" uniqKey="Goh Y" first="Yufen" last="Goh">Yufen Goh</name>
<name sortKey="Hillmer, Axel M" sort="Hillmer, Axel M" uniqKey="Hillmer A" first="Axel M." last="Hillmer">Axel M. Hillmer</name>
<name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name>
<name sortKey="Kubota, Toshiaki" sort="Kubota, Toshiaki" uniqKey="Kubota T" first="Toshiaki" last="Kubota">Toshiaki Kubota</name>
<name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name>
<name sortKey="Lerner, Fabian" sort="Lerner, Fabian" uniqKey="Lerner F" first="Fabian" last="Lerner">Fabian Lerner</name>
<name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name>
<name sortKey="Lischinsky, Ignacio" sort="Lischinsky, Ignacio" uniqKey="Lischinsky I" first="Ignacio" last="Lischinsky">Ignacio Lischinsky</name>
<name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name>
<name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name>
<name sortKey="Mori, Yosai" sort="Mori, Yosai" uniqKey="Mori Y" first="Yosai" last="Mori">Yosai Mori</name>
<name sortKey="Nakano, Satoko" sort="Nakano, Satoko" uniqKey="Nakano S" first="Satoko" last="Nakano">Satoko Nakano</name>
<name sortKey="Ohashi, Tsutomu" sort="Ohashi, Tsutomu" uniqKey="Ohashi T" first="Tsutomu" last="Ohashi">Tsutomu Ohashi</name>
<name sortKey="Peh, Su Qin" sort="Peh, Su Qin" uniqKey="Peh S" first="Su Qin" last="Peh">Su Qin Peh</name>
<name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name>
<name sortKey="Safieh, Leen Abu" sort="Safieh, Leen Abu" uniqKey="Safieh L" first="Leen Abu" last="Safieh">Leen Abu Safieh</name>
<name sortKey="Sakurai, Toshiya" sort="Sakurai, Toshiya" uniqKey="Sakurai T" first="Toshiya" last="Sakurai">Toshiya Sakurai</name>
<name sortKey="Schlottmann, Patricio G" sort="Schlottmann, Patricio G" uniqKey="Schlottmann P" first="Patricio G" last="Schlottmann">Patricio G. Schlottmann</name>
<name sortKey="Sim, Kar Seng" sort="Sim, Kar Seng" uniqKey="Sim K" first="Kar Seng" last="Sim">Kar Seng Sim</name>
<name sortKey="Toh, Kai Yee" sort="Toh, Kai Yee" uniqKey="Toh K" first="Kai-Yee" last="Toh">Kai-Yee Toh</name>
<name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name>
<name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name>
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<country name="Singapour"><noRegion><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
</noRegion>
<name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name>
<name sortKey="Ho, Su Ling" sort="Ho, Su Ling" uniqKey="Ho S" first="Su-Ling" last="Ho">Su-Ling Ho</name>
<name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name>
<name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name>
<name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name>
</country>
<country name="Japon"><noRegion><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name>
</noRegion>
<name sortKey="Aihara, Makoto" sort="Aihara, Makoto" uniqKey="Aihara M" first="Makoto" last="Aihara">Makoto Aihara</name>
<name sortKey="Chihara, Etsuo" sort="Chihara, Etsuo" uniqKey="Chihara E" first="Etsuo" last="Chihara">Etsuo Chihara</name>
<name sortKey="Chuman, Hideki" sort="Chuman, Hideki" uniqKey="Chuman H" first="Hideki" last="Chuman">Hideki Chuman</name>
<name sortKey="Gotoh, Norimoto" sort="Gotoh, Norimoto" uniqKey="Gotoh N" first="Norimoto" last="Gotoh">Norimoto Gotoh</name>
<name sortKey="Hayashi, Ken" sort="Hayashi, Ken" uniqKey="Hayashi K" first="Ken" last="Hayashi">Ken Hayashi</name>
<name sortKey="Higashide, Tomomi" sort="Higashide, Tomomi" uniqKey="Higashide T" first="Tomomi" last="Higashide">Tomomi Higashide</name>
<name sortKey="Ideta, Ryuichi" sort="Ideta, Ryuichi" uniqKey="Ideta R" first="Ryuichi" last="Ideta">Ryuichi Ideta</name>
<name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name>
<name sortKey="Inatani, Masaru" sort="Inatani, Masaru" uniqKey="Inatani M" first="Masaru" last="Inatani">Masaru Inatani</name>
<name sortKey="Inoue, Kenji" sort="Inoue, Kenji" uniqKey="Inoue K" first="Kenji" last="Inoue">Kenji Inoue</name>
<name sortKey="Ishiko, Satoshi" sort="Ishiko, Satoshi" uniqKey="Ishiko S" first="Satoshi" last="Ishiko">Satoshi Ishiko</name>
<name sortKey="Kazama, Shigeyasu" sort="Kazama, Shigeyasu" uniqKey="Kazama S" first="Shigeyasu" last="Kazama">Shigeyasu Kazama</name>
<name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name>
<name sortKey="Kiuchi, Yoshiaki" sort="Kiuchi, Yoshiaki" uniqKey="Kiuchi Y" first="Yoshiaki" last="Kiuchi">Yoshiaki Kiuchi</name>
<name sortKey="Manabe, Shin Ichi" sort="Manabe, Shin Ichi" uniqKey="Manabe S" first="Shin-Ichi" last="Manabe">Shin-Ichi Manabe</name>
<name sortKey="Matsuda, Fumihiko" sort="Matsuda, Fumihiko" uniqKey="Matsuda F" first="Fumihiko" last="Matsuda">Fumihiko Matsuda</name>
<name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name>
<name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name>
<name sortKey="Miyata, Kazunori" sort="Miyata, Kazunori" uniqKey="Miyata K" first="Kazunori" last="Miyata">Kazunori Miyata</name>
<name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name>
<name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name>
<name sortKey="Sugimoto, Takako" sort="Sugimoto, Takako" uniqKey="Sugimoto T" first="Takako" last="Sugimoto">Takako Sugimoto</name>
<name sortKey="Sugiyama, Kazuhisa" sort="Sugiyama, Kazuhisa" uniqKey="Sugiyama K" first="Kazuhisa" last="Sugiyama">Kazuhisa Sugiyama</name>
<name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name>
<name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name>
<name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name>
<name sortKey="Yanagi, Masahide" sort="Yanagi, Masahide" uniqKey="Yanagi M" first="Masahide" last="Yanagi">Masahide Yanagi</name>
<name sortKey="Yoshida, Akitoshi" sort="Yoshida, Akitoshi" uniqKey="Yoshida A" first="Akitoshi" last="Yoshida">Akitoshi Yoshida</name>
<name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name>
</country>
<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name>
</region>
<name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name>
<name sortKey="Alward, Wallace L M" sort="Alward, Wallace L M" uniqKey="Alward W" first="Wallace L. M." last="Alward">Wallace L. M. Alward</name>
<name sortKey="Alward, Wallace L M" sort="Alward, Wallace L M" uniqKey="Alward W" first="Wallace L. M." last="Alward">Wallace L. M. Alward</name>
<name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name>
<name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name>
<name sortKey="Coleman, Anne L" sort="Coleman, Anne L" uniqKey="Coleman A" first="Anne L" last="Coleman">Anne L. Coleman</name>
<name sortKey="Edward, Deepak P" sort="Edward, Deepak P" uniqKey="Edward D" first="Deepak P." last="Edward">Deepak P. Edward</name>
<name sortKey="Fingert, John H" sort="Fingert, John H" uniqKey="Fingert J" first="John H." last="Fingert">John H. Fingert</name>
<name sortKey="Fingert, John H" sort="Fingert, John H" uniqKey="Fingert J" first="John H." last="Fingert">John H. Fingert</name>
<name sortKey="Harder, Jeffrey M" sort="Harder, Jeffrey M" uniqKey="Harder J" first="Jeffrey M." last="Harder">Jeffrey M. Harder</name>
<name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<name sortKey="Howell, Gareth R" sort="Howell, Gareth R" uniqKey="Howell G" first="Gareth R" last="Howell">Gareth R. Howell</name>
<name sortKey="John, Simon W M" sort="John, Simon W M" uniqKey="John S" first="Simon W. M." last="John">Simon W. M. John</name>
<name sortKey="Kang, Jae Hee" sort="Kang, Jae Hee" uniqKey="Kang J" first="Jae Hee" last="Kang">Jae Hee Kang</name>
<name sortKey="Liebmann, Jeffrey M" sort="Liebmann, Jeffrey M" uniqKey="Liebmann J" first="Jeffrey M" last="Liebmann">Jeffrey M. Liebmann</name>
<name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name>
<name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name>
<name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name>
<name sortKey="Rhee, Douglas J" sort="Rhee, Douglas J" uniqKey="Rhee D" first="Douglas J" last="Rhee">Douglas J. Rhee</name>
<name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name>
<name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name>
<name sortKey="Wilson, M Roy" sort="Wilson, M Roy" uniqKey="Wilson M" first="M Roy" last="Wilson">M Roy Wilson</name>
</country>
<country name="Inde"><noRegion><name sortKey="Haripriya, Aravind" sort="Haripriya, Aravind" uniqKey="Haripriya A" first="Aravind" last="Haripriya">Aravind Haripriya</name>
</noRegion>
<name sortKey="Ghosh, Arkasubhra" sort="Ghosh, Arkasubhra" uniqKey="Ghosh A" first="Arkasubhra" last="Ghosh">Arkasubhra Ghosh</name>
<name sortKey="Kumar, Rajesh S" sort="Kumar, Rajesh S" uniqKey="Kumar R" first="Rajesh S" last="Kumar">Rajesh S. Kumar</name>
<name sortKey="Narendran, Kalpana" sort="Narendran, Kalpana" uniqKey="Narendran K" first="Kalpana" last="Narendran">Kalpana Narendran</name>
<name sortKey="Ramakrishnan, Rangappa" sort="Ramakrishnan, Rangappa" uniqKey="Ramakrishnan R" first="Rangappa" last="Ramakrishnan">Rangappa Ramakrishnan</name>
<name sortKey="Shetty, Rohit" sort="Shetty, Rohit" uniqKey="Shetty R" first="Rohit" last="Shetty">Rohit Shetty</name>
<name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name>
<name sortKey="Venkatesh, Rangaraj" sort="Venkatesh, Rangaraj" uniqKey="Venkatesh R" first="Rangaraj" last="Venkatesh">Rangaraj Venkatesh</name>
<name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Uebe, Steffen" sort="Uebe, Steffen" uniqKey="Uebe S" first="Steffen" last="Uebe">Steffen Uebe</name>
</noRegion>
<name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name>
<name sortKey="Krumbiegel, Mandy" sort="Krumbiegel, Mandy" uniqKey="Krumbiegel M" first="Mandy" last="Krumbiegel">Mandy Krumbiegel</name>
<name sortKey="Mardin, Christian" sort="Mardin, Christian" uniqKey="Mardin C" first="Christian" last="Mardin">Christian Mardin</name>
<name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Pasutto, Francesca" sort="Pasutto, Francesca" uniqKey="Pasutto F" first="Francesca" last="Pasutto">Francesca Pasutto</name>
<name sortKey="Reis, Andre" sort="Reis, Andre" uniqKey="Reis A" first="André" last="Reis">André Reis</name>
<name sortKey="Schaeffeler, Elke" sort="Schaeffeler, Elke" uniqKey="Schaeffeler E" first="Elke" last="Schaeffeler">Elke Schaeffeler</name>
<name sortKey="Schloetzer Schrehardt, Ursula" sort="Schloetzer Schrehardt, Ursula" uniqKey="Schloetzer Schrehardt U" first="Ursula" last="Schloetzer-Schrehardt">Ursula Schloetzer-Schrehardt</name>
<name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name>
<name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name>
<name sortKey="Schwab, Matthias" sort="Schwab, Matthias" uniqKey="Schwab M" first="Matthias" last="Schwab">Matthias Schwab</name>
<name sortKey="Weisschuh, Nicole" sort="Weisschuh, Nicole" uniqKey="Weisschuh N" first="Nicole" last="Weisschuh">Nicole Weisschuh</name>
<name sortKey="Welge Luessen, Ulrich Christoph" sort="Welge Luessen, Ulrich Christoph" uniqKey="Welge Luessen U" first="Ulrich-Christoph" last="Welge-Luessen">Ulrich-Christoph Welge-Luessen</name>
</country>
<country name="Australie"><noRegion><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name>
</noRegion>
<name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
<name sortKey="Coote, Michael" sort="Coote, Michael" uniqKey="Coote M" first="Michael" last="Coote">Michael Coote</name>
<name sortKey="Coote, Michael" sort="Coote, Michael" uniqKey="Coote M" first="Michael" last="Coote">Michael Coote</name>
<name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name>
<name sortKey="Crowston, Jonathan G" sort="Crowston, Jonathan G" uniqKey="Crowston J" first="Jonathan G" last="Crowston">Jonathan G. Crowston</name>
<name sortKey="Crowston, Jonathan G" sort="Crowston, Jonathan G" uniqKey="Crowston J" first="Jonathan G" last="Crowston">Jonathan G. Crowston</name>
<name sortKey="Fogarty, Rhys A" sort="Fogarty, Rhys A" uniqKey="Fogarty R" first="Rhys A." last="Fogarty">Rhys A. Fogarty</name>
<name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name>
<name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
</country>
<country name="Russie"><noRegion><name sortKey="Astakhov, Yury S" sort="Astakhov, Yury S" uniqKey="Astakhov Y" first="Yury S." last="Astakhov">Yury S. Astakhov</name>
</noRegion>
<name sortKey="Akopov, Evgeny L" sort="Akopov, Evgeny L" uniqKey="Akopov E" first="Evgeny L." last="Akopov">Evgeny L. Akopov</name>
<name sortKey="Astakhov, Sergei Y" sort="Astakhov, Sergei Y" uniqKey="Astakhov S" first="Sergei Y." last="Astakhov">Sergei Y. Astakhov</name>
<name sortKey="Dubina, Michael" sort="Dubina, Michael" uniqKey="Dubina M" first="Michael" last="Dubina">Michael Dubina</name>
<name sortKey="Dubina, Michael" sort="Dubina, Michael" uniqKey="Dubina M" first="Michael" last="Dubina">Michael Dubina</name>
<name sortKey="Vysochinskaya, Vera" sort="Vysochinskaya, Vera" uniqKey="Vysochinskaya V" first="Vera" last="Vysochinskaya">Vera Vysochinskaya</name>
</country>
<country name="Arabie saoudite"><noRegion><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name>
</noRegion>
<name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name>
<name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name>
</country>
<country name="Mexique"><noRegion><name sortKey="Zenteno, Juan C" sort="Zenteno, Juan C" uniqKey="Zenteno J" first="Juan C." last="Zenteno">Juan C. Zenteno</name>
</noRegion>
<name sortKey="Guadarrama Vallejo, Dalia" sort="Guadarrama Vallejo, Dalia" uniqKey="Guadarrama Vallejo D" first="Dalia" last="Guadarrama-Vallejo">Dalia Guadarrama-Vallejo</name>
<name sortKey="Guadarrama Vallejo, Dalia" sort="Guadarrama Vallejo, Dalia" uniqKey="Guadarrama Vallejo D" first="Dalia" last="Guadarrama-Vallejo">Dalia Guadarrama-Vallejo</name>
<name sortKey="Zenteno, Juan C" sort="Zenteno, Juan C" uniqKey="Zenteno J" first="Juan C." last="Zenteno">Juan C. Zenteno</name>
</country>
<country name="Turquie"><noRegion><name sortKey="Nilgun, Yildirim" sort="Nilgun, Yildirim" uniqKey="Nilgun Y" first="Yildirim" last="Nilgün">Yildirim Nilgün</name>
</noRegion>
<name sortKey="O Uz, Cilingir" sort="O Uz, Cilingir" uniqKey="O Uz C" first="Çilingir" last="O Uz">Çilingir O Uz</name>
<name sortKey="Yetkin, Yaz" sort="Yetkin, Yaz" uniqKey="Yetkin Y" first="Yaz" last="Yetkin">Yaz Yetkin</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Zarnowski, Tomasz" sort="Zarnowski, Tomasz" uniqKey="Zarnowski T" first="Tomasz" last="Zarnowski">Tomasz Zarnowski</name>
</noRegion>
<name sortKey="Kosior Jarecka, Ewa" sort="Kosior Jarecka, Ewa" uniqKey="Kosior Jarecka E" first="Ewa" last="Kosior-Jarecka">Ewa Kosior-Jarecka</name>
<name sortKey="Lukasik, Urszula" sort="Lukasik, Urszula" uniqKey="Lukasik U" first="Urszula" last="Lukasik">Urszula Lukasik</name>
</country>
<country name="Iran"><noRegion><name sortKey="Pakravan, Mohammad" sort="Pakravan, Mohammad" uniqKey="Pakravan M" first="Mohammad" last="Pakravan">Mohammad Pakravan</name>
</noRegion>
<name sortKey="Al Jasim, Leyla" sort="Al Jasim, Leyla" uniqKey="Al Jasim L" first="Leyla" last="Al-Jasim">Leyla Al-Jasim</name>
<name sortKey="Al Shahwan, Sami" sort="Al Shahwan, Sami" uniqKey="Al Shahwan S" first="Sami" last="Al Shahwan">Sami Al Shahwan</name>
<name sortKey="Beni, Afsaneh Naderi" sort="Beni, Afsaneh Naderi" uniqKey="Beni A" first="Afsaneh Naderi" last="Beni">Afsaneh Naderi Beni</name>
<name sortKey="Kanavi, Mozhgan Rezaei" sort="Kanavi, Mozhgan Rezaei" uniqKey="Kanavi M" first="Mozhgan Rezaei" last="Kanavi">Mozhgan Rezaei Kanavi</name>
<name sortKey="Owaidhah, Ohoud" sort="Owaidhah, Ohoud" uniqKey="Owaidhah O" first="Ohoud" last="Owaidhah">Ohoud Owaidhah</name>
<name sortKey="Yazdani, Shahin" sort="Yazdani, Shahin" uniqKey="Yazdani S" first="Shahin" last="Yazdani">Shahin Yazdani</name>
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   |texte=   A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome
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Serveur d'exploration sur les relations entre la France et l'Australie

A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome

A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome

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	Serveur d'exploration sur les relations entre la France et l'Australie
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